U-73343

• UNSPSC Description:

  U-73343, works as a protonophore, is an inactive analog of U-73122 and can be used as a negative control. U-73343 dose-dependently inhibits acid secretion irrespective of the stimulant. U-73122 is a phospholipase C (PLC) and 5-LO (5-lipoxygenase) inhibitor with an IC50 of 1-2.1 μM for PLC[1][2].

• Target Antigen:

  Phospholipase

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/u-73343.html

• Purity:

  99.39

• Solubility:

  DMSO : 3.33 mg/mL (ultrasonic;warming;heat to 60°C)

• Smiles:

  O=C(CC1)N(CCCCCCN[C@H]2CCC3C4CCC5=C(C=CC(OC)=C5)C4CC[C@]23C)C1=O

• Molecular Weight:

  466.66

• References & Citations:

  [1]Muto Y, et al. The putative phospholipase C inhibitor U73122 and its negative control, U73343, elicit unexpected effects on the rabbit parietal cell. J Pharmacol Exp Ther. 1997 Sep;282(3):1379-88.|[2]A Tatrai, et al. U-73122, a phospholipase C antagonist, inhibits effects of endothelin-1 and parathyroid hormone on signal transduction in UMR-106 osteoblastic cells. Biochim Biophys Acta. 1994 Dec 30;1224(3):575-82.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  142878-12-4