p-nitro-Pifithrin-α
CAT:
804-HY-130437-01
Size:
10 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
p-nitro-Pifithrin-α
- CAS Number: 389850-21-9
- UNSPSC Description: p-nitro-Pifithrin-α, a cell-permeable analog of pifithrin-α, is a potent p53 inhibitor. p-nitro-Pifithrin-α suppresses p53-mediated TGF-β1 expression in HK-2 cells. p-nitro-Pifithrin-α inhibits the activation of caspase-3 by Zika virus (ZIKV) strains. p-nitro-Pifithrin-α attenuates steatosis and liver injury in mice fed a high-fat diet [4]. non-alcoholic fatty liver disease[1][2][3].
- Target Antigen: Caspase; MDM-2/p53; TGF-β Receptor
- Type: Reference compound
- Related Pathways: Apoptosis;TGF-beta/Smad
- Field of Research: Infection; Metabolic Disease
- Assay Protocol: https://www.medchemexpress.com/p-nitro-pifithrin-α.html
- Purity: 97.0
- Solubility: DMSO : 1 mg/mL (ultrasonic;warming)
- Smiles: N=C1SC2=C(CCCC2)N1CC(C3=CC=C([N+]([O-])=O)C=C3)=O.[H]Br
- Molecular Weight: 398.27
- References & Citations: [1]Shimizu H, Yisireyili M, Nishijima F, Niwa T. Indoxyl sulfate enhances p53-TGF-β1-Smad3 pathway in proximal tubular cells. Am J Nephrol. 2013;37(2):97-103.|[2]Zhang F, et al. Molecular signatures associated with ZIKV exposure in human cortical neural progenitors. Nucleic Acids Res. 2016 Oct 14;44(18):8610-8620.|[3]Derdak Z, et al. Inhibition of p53 attenuates steatosis and liver injury in a mouse model of non-alcoholic fatty liver disease. J Hepatol. 2013 Apr;58(4):785-91.
- Shipping Conditions: Blue Ice
- Storage Conditions: -20°C (Powder, sealed storage, away from moisture)
- Clinical Information: No Development Reported