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p-nitro-Pifithrin-α

CAT: 0026-B2845-5Size: 5 mgDry Ice: NoHazardous: No
CAT#:0026-B2845-5Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
p-nitro-Pifithrin-α is a cell-permeable analog of pifithrin-α. Pifithrin-α is an inhibitor of p53 that blocks p53-dependent apoptosis. p-nitro-Pifithrin-α blocks p53-mediated expression of p21/WAF1 and apoptosis in cortical neurons more potently than pifithrin-α. It suppresses the expression of TGF-β1 in human proximal tubular cells (HK-2 cells) at a concentration of 10 μM. It reduces hepatic triglyceride accumulation and lipotoxicity in mice fed a high fat diet.
Shipping Conditions
RT
Storage Conditions
-20ºC
Shelf Life
36 months

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