Pifithrin-α (hydrobromide)
CAT:
804-HY-15484-03
Size:
10 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Pifithrin-α (hydrobromide)
- CAS Number: 63208-82-2
- UNSPSC Description: Pifithrin-α hydrobromide is a p53 inhibitor which blocks its transcriptional activity and prevents cells from apoptosis. Pifithrin-α hydrobromide is also an aryl hydrocarbon receptor (AhR) agonist.
- Target Antigen: Apoptosis; Aryl Hydrocarbon Receptor; Ferroptosis; MDM-2/p53
- Type: Reference compound
- Related Pathways: Apoptosis;Immunology/Inflammation
- Applications: Cancer-programmed cell death
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/Pifithrin-_alpha_-hydrobromide.html
- Solubility: DMSO : ≥ 50 mg/mL|H2O : 1.25 mg/mL (ultrasonic)
- Smiles: N=C1SC2=C(CCCC2)N1CC(C3=CC=C(C)C=C3)=O.[H]Br
- Molecular Weight: 367.30386
- References & Citations: [1]Yu W, et al. Cyclosporine A Suppressed Glucose Oxidase Induced P53 Mitochondrial Translocation and Hepatic Cell Apoptosis through Blocking Mitochondrial Permeability Transition. Int J Biol Sci. 2016 Jan 1;12(2):198-209.|[2]Hoagland MS, et al. The p53 Inhibitor Pifithrin-α Is a Potent Agonist of the Aryl Hydrocarbon Receptor. J Pharmacol Exp Ther. 2005 Aug;314(2):603-10.|[3]Kuang SQ, et al. FOXE3 mutations predispose to thoracic aortic aneurysms and dissections. J Clin Invest. 2016 Mar 1;126(3):948-61.
- Shipping Conditions: Room Temperature
- Clinical Information: No Development Reported