P-nitro-Pifithrin-?

• Target :

  TGF-beta/Smad|||Others|||Caspase|||MDM-2/p53

• Related Pathways :

  Others|||Stem Cells|||Proteases/Proteasome|||Apoptosis

• Bioactivity :

  P-nitro-Pifithrin-? is a cell-permeable analog of pifithrin-?, a potent p53 inhibitor. It suppresses p53-mediated TGF-?1 expression in HK-2 cells and inhibits the activation of caspase-3 by Zika virus (ZIKV) strains. Moreover, p-nitro-Pifithrin-? attenuates steatosis and liver injury in mice subjected to a high-fat diet, mitigating the effects of non-alcoholic fatty liver disease [1] [2] [3] [4].

• Smiles :

  Br.[O-][N+](=O)c1ccc(cc1)C(=O)Cn1c2CCCCc2sc1=N

• Molecular Formula :

  C15H16BrN3O3S

• Molecular Weight :

  398.27

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  389850-21-9