P-nitro-Pifithrin-α

CAT: 0931-T21978-01Size: 1 mgDry Ice: NoHazardous: No

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CAT#:0931-T21978-01Size:1 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

389850-21-9

Target

TGF-beta/Smad, Others, Caspase, MDM-2/p53

Related Pathways

Others, Stem Cells, Proteases/Proteasome, Apoptosis

Bioactivity

P-nitro-Pifithrin-α is a cell-permeable analog of pifithrin-α, a potent p53 inhibitor. It suppresses p53-mediated TGF-β1 expression in HK-2 cells and inhibits the activation of caspase-3 by Zika virus (ZIKV) strains. Moreover, p-nitro-Pifithrin-α attenuates steatosis and liver injury in mice subjected to a high-fat diet, mitigating the effects of non-alcoholic fatty liver disease [1] [2] [3] [4].

Smiles

Br.[O-][N+](=O)c1ccc(cc1)C(=O)Cn1c2CCCCc2sc1=N

Molecular Formula

C15H16BrN3O3S

Molecular Weight

398.27

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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Catalog	Name
B2845-5	p-nitro-Pifithrin-α
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MBS5802308	p-nitro-Pifithrin-alpha
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