P-nitro-Pifithrin-?

• Target:

  TGF-beta/Smad|||Others|||Caspase|||MDM-2/p53

• Related Pathways:

  Others|||Stem Cells|||Proteases/Proteasome|||Apoptosis

• Bioactivity:

  P-nitro-Pifithrin-? is a cell-permeable analog of pifithrin-?, a potent p53 inhibitor. It suppresses p53-mediated TGF-?1 expression in HK-2 cells and inhibits the activation of caspase-3 by Zika virus (ZIKV) strains. Moreover, p-nitro-Pifithrin-? attenuates steatosis and liver injury in mice subjected to a high-fat diet, mitigating the effects of non-alcoholic fatty liver disease [1] [2] [3] [4].

• Smiles:

  Br.[O-][N+] (=O) c1ccc (cc1) C (=O) Cn1c2CCCCc2sc1=N

• Molecular Formula:

  C15H16BrN3O3S

• Molecular Weight:

  398.27

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  389850-21-9