Pifithrin-α, p-Nitro, Cyclic

Pifithrin-α, p-Nitro, Cyclic

• Product Name Alternative: PFN-α
• CAS Number: 60477-38-5
• UNSPSC Description: Pifithrin-α, p-Nitro, Cyclic (PFN-α) is cell-permeable and active-form p53 inhibitor. Pifithrin-α, p-Nitro, Cyclic is one order magnitude more active than Pifithrin-α in protecting cortical neurons exposed to Etoposide (ED50=30 nM). Pifithrin-α, p-Nitro, Cyclic behaves as a p53 posttranscriptional activity inhibitor. Pifithrin-α, p-Nitro, Cyclic do not prevent p53 phosphorylation on the S15 residue[1][2].
• Target Antigen: MDM-2/p53
• Type: Reference compound
• Related Pathways: Apoptosis
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/pifithrin-alpha-p-nitro-cyclic.html
• Purity: 99.73
• Solubility: DMF : 12.5 mg/mL (ultrasonic)|DMSO : 5 mg/mL (ultrasonic)
• Smiles: O=[N+]([O-])C1=CC=C(C2=CN3C(SC4=C3CCCC4)=N2)C=C1
• Molecular Weight: 299.35
• References & Citations: [1]Pietrancosta N, et al. Imino-tetrahydro-benzothiazole derivatives as p53 inhibitors: discovery of a highly potent in vivo inhibitor and its action mechanism. J Med Chem. 2006 Jun 15;49(12):3645-52.|[2]Dinca EB, et al. p53 Small-molecule inhibitor enhances temozolomide cytotoxic activity against intracranial glioblastoma xenografts. Cancer Res. 2008 Dec 15;68(24):10034-9.
• Shipping Conditions: Blue Ice
• Storage Conditions: -20°C (Powder, stored under nitrogen)
• Clinical Information: No Development Reported