CDK12-IN-6

• UNSPSC Description:

  CDK12-IN-6, a pyrazolotriazine, is a potent CDK12 inhibitor with an IC50 of 1.19 μM at high ATP (2 mM). CDK12-IN-6 has no effect on CDK2/Cyclin E (IC50>20 μM) and CDK9/Cyclin T1 (IC50>20 μM) at high ATP (2 mM) (WO2021116178A1)[1].

• Target Antigen:

  CDK

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/cdk12-in-6.html

• Smiles:

  FC1=C2C(N=C(CNC3=NC(N4CCNCC4)=NC5=C(C6CC6)C=NN53)N2)=CC=C1F

• Molecular Weight:

  425.44

• References & Citations:

  [1]Kai Thede, et al. Pyrazolotriazines. WO2021116178A1.

• Shipping Conditions:

  Room Temperature

• CAS Number:

  2651196-71-1