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CDK12/13-IN-2

CAT: 0804-HY-173042Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-173042Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CDK12/13-IN-2 (Compound 24) is a covalent inhibitor of CDK12/13, with IC50 values of 15.5 nM and 12.2 nM for CDK12 and CDK13, respectively. CDK12/13-IN-2 can inhibit the proliferation of breast cancer cells and can be used in the research of triple-negative breast cancer[1].
CAS Number
3076450-41-1
UNSPSC
12352005
Target
CDK
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
C=CC(NC1=CC=C(C2=NN3C(C=C2)=NC(CC(NC4=NNC(C5CCC5)=C4)=O)=C3)C=C1F)=O
Molecular Formula
C24H22FN7O2
Molecular Weight
459.48
References & Citations
[1]Xia M, Li Z, et al. Discovery of novel imidazo[1,2-b]pyridazine derivatives as potent covalent inhibitors of CDK12/13. Eur J Med Chem. 2025 Apr 15;288:117378.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK12; CDK13

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