CDK12-IN-8

• Description:

  CDK12-IN-8 (Compound Cpd143) is an orally active and highly selective inhibitor of cyclin-dependent kinase 12 (CDK12) . CDK12-IN-8 inhibits CDK12-mediated phosphorylation of the C-terminal domain (CTD) serine 2 of RNA polymerase II, interfering with gene transcription elongation and DNA damage repair pathways. CDK12-IN-8 is promising for research of cancers with high CDK12 expression such as small cell lung cancer and triple-negative breast cancer[1].

• UNSPSC:

  12352005

• Target:

  CDK

• Related Pathways:

  Cell Cycle/DNA Damage

• Field of Research:

  Cancer

• Smiles:

  N#CC1=CC2=NN=C (N2C=C1) [C@@H] (CCC3) C[C@@H]3NC4=NC=C (C (F) (F) F) C (OC5COC5) =N4

• Molecular Formula:

  C21H20F3N7O2

• Molecular Weight:

  459.42

• References & Citations:

  [1]Guillaume BENOIT, et al. Inhibitors of cyclin‑dependent kinase 12 (cdk12) . WO2023091726A1. 2023-05-25.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  CDK12

• CAS Number:

  2928619-86-5