CDK12-IN-8

CAT: 0804-HY-171786Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-171786Size:1 Each
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Description
CDK12-IN-8 (Compound Cpd143) is an orally active and highly selective inhibitor of cyclin-dependent kinase 12 (CDK12) . CDK12-IN-8 inhibits CDK12-mediated phosphorylation of the C-terminal domain (CTD) serine 2 of RNA polymerase II, interfering with gene transcription elongation and DNA damage repair pathways. CDK12-IN-8 is promising for research of cancers with high CDK12 expression such as small cell lung cancer and triple-negative breast cancer[1].
CAS Number
[2928619-86-5]
UNSPSC
12352005
Target
CDK
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Cancer
Smiles
N#CC1=CC2=NN=C(N2C=C1)[C@@H](CCC3)C[C@@H]3NC4=NC=C(C(F)(F)F)C(OC5COC5)=N4
Molecular Formula
C21H20F3N7O2
Molecular Weight
459.42
References & Citations
[1]Guillaume BENOIT, et al. Inhibitors of cyclin‑dependent kinase 12 (cdk12) . WO2023091726A1. 2023-05-25.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK12

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