CDK12-IN-5

• UNSPSC Description:

  CDK12-IN-5, a pyrazolotriazine, is a potent CDK12 inhibitor with an IC50 of 23.9 nM at high ATP (2 mM). CDK12-IN-5 has no effect on CDK2/Cyclin E (IC50=173 μM) and CDK9/Cyclin T1 (IC50=127 μM) at high ATP (2 mM) (WO2021116178A1)[1].

• Target Antigen:

  CDK

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/cdk12-in-5.html

• Smiles:

  FC(C1=C2N(N=C1)C(NCC3=NC4=CC=C(F)C(F)=C4N3)=NC(N5CCOCC5)=N2)(F)F

• Molecular Weight:

  454.36

• References & Citations:

  [1]Kai Thede, et al. Pyrazolotriazines. WO2021116178A1.

• Shipping Conditions:

  Room Temperature

• CAS Number:

  2651200-35-8