CDK12-IN-4

• Description:

  CDK12-IN-4, a pyrazolotriazine, is a potent CDK12 inhibitor with an IC50 of 0.641 μM at high ATP (2 mM) . CDK12-IN-4 has no effect on CDK2/Cyclin E (IC50>20 μM) and CDK9/Cyclin T1 (IC50>20 μM) at high ATP (2 mM) (WO2021116178A1) [1].

• UNSPSC:

  12352005

• Target:

  CDK

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/cdk12-in-4.html

• Solubility:

  10 mM in DMSO

• Smiles:

  FC1=C(F)C2=C(N=C(CNC3=NC(N4CCOCC4)=NC5=C(C6CC6)C=NN35)N2)C=C1

• Molecular Formula:

  C20H20F2N8O

• Molecular Weight:

  426.42

• References & Citations:

  [1]Kai Thede, et al. Pyrazolotriazines. WO2021116178A1.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  CDK12; CDK2; CDK9

• CAS Number:

  2651196-69-7