CDK12-IN-4

CAT: 0804-HY-139327Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-139327Size:1 Each
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CDK12-IN-4, a pyrazolotriazine, is a potent CDK12 inhibitor with an IC50 of 0.641 μM at high ATP (2 mM) . CDK12-IN-4 has no effect on CDK2/Cyclin E (IC50>20 μM) and CDK9/Cyclin T1 (IC50>20 μM) at high ATP (2 mM) (WO2021116178A1) [1].
CAS Number
[2651196-69-7]
UNSPSC
12352005
Target
CDK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cdk12-in-4.html
Solubility
10 mM in DMSO
Smiles
FC1=C(F)C2=C(N=C(CNC3=NC(N4CCOCC4)=NC5=C(C6CC6)C=NN35)N2)C=C1
Molecular Formula
C20H20F2N8O
Molecular Weight
426.42
References & Citations
[1]Kai Thede, et al. Pyrazolotriazines. WO2021116178A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK12; CDK2; CDK9

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