CDK12-IN-4

• Target :

  Others|||CDK

• Related Pathways :

  Cell Cycle/Checkpoint|||Others

• Bioactivity :

  CDK12-IN-4, a pyrazolotriazine compound, exhibits potent inhibition of CDK12 by achieving an IC50 value of 0.641 ?M, utilizing high ATP levels (2 mM) . Notably, CDK12-IN-4 does not impact CDK2/Cyclin E (IC50 > 20 ?M) or CDK9/Cyclin T1 (IC50 > 20 ?M) under the influence of high ATP (2 mM) levels (WO2021116178A1) .

• Smiles :

  Fc1ccc2nc(CNc3nc(nc4c(cnn34)C3CC3)N3CCOCC3)[nH]c2c1F

• Molecular Formula :

  C20H20F2N8O

• Molecular Weight :

  426.432

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  2651196-69-7