CDK12-IN-8

• Target:

  CDK

• Related Pathways:

  Cell Cycle/Checkpoint

• Bioactivity:

  CDK12-IN-8 (Compound Cpd143) is an orally active, highly selective inhibitor of cyclin-dependent kinase 12 (CDK12) . It blocks the phosphorylation of serine 2 in the C-terminal domain (CTD) of RNA polymerase II, thereby interfering with gene transcription elongation and DNA damage repair pathways. CDK12-IN-8 holds potential for research in cancers with high CDK12 expression, such as small cell lung cancer and triple-negative breast cancer.

• Smiles:

  N([C@H]1C[C@@H](C=2N3C(=NN2)C=C(C#N)C=C3)CCC1)C=4N=C(OC5COC5)C(C(F)(F)F)=CN4

• Molecular Formula:

  C21H20F3N7O2

• Molecular Weight:

  459.42

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2928619-86-5