BMS-963272

• UNSPSC Description:

  BMS-963272 is an orally active and selective MGAT2 inhibitor (IC50 = 7.1 nM), used for the study of metabolic disorders and inflammatory diseases[1][2].

• Target Antigen:

  Acyltransferase

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Field of Research:

  Metabolic Disease; Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/bms-963272.html

• Purity:

  99.92

• Solubility:

  DMSO : 250 mg/mL (ultrasonic)

• Smiles:

  CC1=CC=C(C2=C(C(N[C@@](C3=CC=C(C=C3)OCCCC(F)(F)F)(C(F)(F)F)C2)=O)C4=NN=NN4)C=C1

• Molecular Weight:

  525.45

• References & Citations:

  [1]Turdi H, et al. Screening Hit to Clinical Candidate: Discovery of BMS-963272, a Potent, Selective MGAT2 Inhibitor for the Treatment of Metabolic Disorders. J Med Chem. 2021 Oct 14;64(19):14773-14792. |[2]Cheng D, et al. MGAT2 inhibitor decreases liver fibrosis and inflammation in murine NASH models and reduces body weight in human adults with obesity. Cell Metab. 2022 Nov 1;34(11):1732-1748.e5.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  Phase 1

• CAS Number:

  1441057-15-3