PROTAC BRD4 Degrader-1

CAT:
804-HY-133131-01
Size:
1 mg
  • Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
  • Dry Ice Shipment: No
PROTAC BRD4 Degrader-1 - image 1

PROTAC BRD4 Degrader-1

  • UNSPSC Description:

    PROTAC BRD4 Degrader-1 is a PROTAC connected by ligands for Cereblon and BRD4 with an IC50 of 41.8 nM against BRD4 BD1. PROTAC BRD4 Degrader-1 can effectively degrade BRD4 protein and suppress c-Myc expression[1].
  • Target Antigen:

    Epigenetic Reader Domain; PROTACs
  • Type:

    Reference compound
  • Related Pathways:

    Epigenetics;PROTAC
  • Field of Research:

    Cancer
  • Assay Protocol:

    https://www.medchemexpress.com/protac-brd4-degrader-1.html
  • Smiles:

    O=C(NC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)COCCN4N=NC(CN5C(N(C)C6=C(C=C(C7=C(C)ON=C7C)C=C6)C5C8=CC=CC=C8)=O)=C4
  • Molecular Weight:

    771.78
  • References & Citations:

    [1]Zhang F, et al. Discovery of a new class of PROTAC BRD4 degraders based on a dihydroquinazolinone derivative and lenalidomide/pomalidomide.Bioorg Med Chem. 2020 Jan 1;28(1):115228.
  • Shipping Conditions:

    Room Temperature
  • CAS Number:

    2133360-00-4