PROTAC BRD4 Degrader-13

PROTAC BRD4 Degrader-13

• CAS Number: 2417370-71-7
• UNSPSC Description: PROTAC BRD4 Degrader-13 (compound 9d) is a von Hippel-Lindau system-based PROTAC BRD4 degrader with a linker that can be coupled to ADC antibodies to form PACs (PROTAC-antibody Conjugates). PROTAC BRD4 Degrader-13 can be coupled to STEAP1 and CLL1 antibodies to degrade BRD4 protein in PC3 prostate cancer cells with DC50 values ​​of 0.025 nM and 6.0 nM, respectively[1].
• Target Antigen: Epigenetic Reader Domain; PROTAC-Linker Conjugates for PAC
• Type: ADC Related
• Related Pathways: Antibody-drug Conjugate/ADC Related;Epigenetics;PROTAC
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/protac-brd4-degrader-13.html
• Solubility: 10 mM in DMSO
• Smiles: CC(N=CS1)=C1C2=CC=C(CNC([C@@H]3C[C@H](CN3C([C@@H](NC(CCCCCCCCCCNC(C4=CC(N(C5=NC=C(F)C=C5F)CC6=CNC7=C6C8=CN(C)C7=O)=C8C=C4CS(=O)(C)=O)=O)=O)C(C)(C)C)=O)OP(OP(OCCNC(CCCCCN9C(C=CC9=O)=O)=O)(O)=O)(O)=O)=O)C=C2
• Molecular Weight: 1492.54
• References & Citations: [1]Dragovich PS, et, al. Antibody-Mediated Delivery of Chimeric BRD4 Degraders. Part 2: Improvement of In Vitro Antiproliferation Activity and In Vivo Antitumor Efficacy. J Med Chem. 2021 Mar 11;64(5):2576-2607.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported