PROTAC BRD4 Degrader-6

PROTAC BRD4 Degrader-6

• CAS Number: 2410947-56-5
• UNSPSC Description: PROTAC BRD4 Degrader-6 (compound 32a) is a potent small-molecule BRD4PROTAC degrader with IC50 value of 2.7 nM for BRD4 BD1. PROTAC BRD4 Degrader-6 potently degrades BRD4 protein and inhibits the expression of c-Myc. PROTAC BRD4 Degrader-6 inhibits the proliferation of pancreatic cancer cell line BxPC3 and induces apoptosis. PROTAC BRD4 Degrader-6 can be used for human pancreatic cancer research (Pink: Mivebresib (HY-100015); Black: linker, Azido-PEG1-CH2CO2H (HY-108369); Blue: Lenalidomide (HY-A0003))[1].
• Target Antigen: Apoptosis; Caspase; c-Myc; Epigenetic Reader Domain; PROTACs
• Type: Reference compound
• Related Pathways: Apoptosis;Epigenetics;PROTAC
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/protac-brd4-degrader-6.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(C(N1)=CC(C(C2=CC(NS(=O)(CC)=O)=CC=C2OC3=CC=C(F)C=C3F)=CN4C)=C1C4=O)NCC5=CN(CCOCC(NC6=CC=CC7=C6CN(C(CC8)C(NC8=O)=O)C7=O)=O)N=N5
• Molecular Weight: 926.90
• References & Citations: [1]Zhang J, et al. Development of small-molecule BRD4 degraders based on pyrrolopyridone derivative. Bioorg Chem. 2020 Jun;99:103817.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported