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PROTAC BRD4 Degrader-6

CAT: 0804-HY-131203Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-131203Size:1 Each
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Description
PROTAC BRD4 Degrader-6 (compound 32a) is a potent small-molecule BRD4PROTAC degrader with IC50 value of 2.7 nM for BRD4 BD1. PROTAC BRD4 Degrader-6 potently degrades BRD4 protein and inhibits the expression of c-Myc. PROTAC BRD4 Degrader-6 inhibits the proliferation of pancreatic cancer cell line BxPC3 and induces apoptosis. PROTAC BRD4 Degrader-6 can be used for human pancreatic cancer research (Pink: Mivebresib ; Black: linker, Azido-PEG1-CH2CO2H (HY-108369) ; Blue: Lenalidomide (HY-A0003) ).
CAS Number
2410947-56-5
UNSPSC
12352005
Target
Apoptosis; Caspase; c-Myc; Epigenetic Reader Domain; PROTACs
Type
Reference compound
Related Pathways
Apoptosis; Epigenetics; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-brd4-degrader-6.html
Solubility
10 mM in DMSO
Smiles
O=C(C(N1)=CC(C(C2=CC(NS(=O)(CC)=O)=CC=C2OC3=CC=C(F)C=C3F)=CN4C)=C1C4=O)NCC5=CN(CCOCC(NC6=CC=CC7=C6CN(C(CC8)C(NC8=O)=O)C7=O)=O)N=N5
Molecular Formula
C43H40F2N10O10S
Molecular Weight
926.90
References & Citations
[1]Zhang J, et al. Development of small-molecule BRD4 degraders based on pyrrolopyridone derivative. Bioorg Chem. 2020 Jun;99:103817.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
BRD4; Caspase 3

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