PROTAC BRD4 Degrader-26

• UNSPSC Description:

  PROTAC BRD4 Degrader-26 (PROTAC-2) is a photo-regulated PROTAC, which degrades 80% BRD4 at 1 μM by using photocleavable linker. PROTAC BRD4 Degrader-26 will be deactivated by UV light. (Pink: ligand for target protein BRD4 ligand 6 (HY-161651); Black: linker (HY-161653); Blue: E3 ligase ligand Thalidomide 4-fluoride (HY-41547))[1]

• Target Antigen:

  Epigenetic Reader Domain; PROTACs

• Type:

  Reference compound

• Related Pathways:

  Epigenetics;PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/protac-brd4-degrader-26.html

• Smiles:

  O=C(C1=C(NCCCOC2=CC(COC(NCCCNC(C[C@H]3C4=NN=C(C)N4C(SC(C)=C5C)=C5C(C6=CC=C(Cl)C=C6)=N3)=O)=O)=C([N+]([O-])=O)C=C2)C=CC=C17)N(C8C(NC(CC8)=O)=O)C7=O

• Molecular Weight:

  965.43

• References & Citations:

  [1]Xu H, et al., Photo-regulated PROTACs: A novel tool for temporal control of targeted protein degradation. Bioorg Med Chem Lett. 2024 Jul 15;107:129778.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  3050769-37-1