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PROTAC BRD4 Degrader-9

CAT: 0931-T40072-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0931-T40072-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2417370-42-2
Target
Epigenetic Reader Domain, PROTACs, Others
Related Pathways
Others, Chromatin/Epigenetic, PROTAC
Bioactivity
PROTAC BRD4 Degrader-9 (compound 8a) is a novel chemical compound comprising ligands for von Hippel-Lindau and BRD4, connected by a PROTAC moiety. This compound efficiently degrades the BRD4 protein in PC3 prostate cancer cells. When conjugated with STEAP1 and CLL1 antibodies, PROTAC BRD4 Degrader-9 exhibits potent activity, with respective DC50 values of 0.86 nM and 7.6 nM.
Smiles
Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@H](CN2C(=O)[C@@H](NC(=O)COCCOCCOCCNC(=O)c2cc3N(Cc4c[nH]c5c4c(cn(C)c5=O)-c3cc2CS(C)(=O)=O)c2ncc(F)cc2F)C(C)(C)C)OC(=O)OCC(C)(C)SS(C)(=O)=O)cc1
Molecular Formula
C59H71F2N9O15S4
Molecular Weight
1312.5
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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