PROTAC BRD4 Degrader-14

• UNSPSC Description:

  PROTAC BRD4 Degrader-14 is a PROTAC connected by ligands for von Hippel-Lindau and BRD4, with IC50s of 1.8 nM and 1.7 nM for BRD4 BD1 and BD2, respectively. PROTAC BRD4 Degrader-14 is capable of potently degrading the BRD4 protein in PC3 prostate cancer cells[1].

• Target Antigen:

  Epigenetic Reader Domain; PROTACs

• Type:

  Reference compound

• Related Pathways:

  Epigenetics;PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/protac-brd4-degrader-14.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O[C@H](C[C@H]1C(NCC2=CC=C(C=C2)C3=C(N=CS3)C)=O)CN1C([C@@H](NC(COCCC4=CC(OCCNC(C5=CC(N(C6=NC=C(F)C=C6F)CC7=CNC8=C7C9=CN(C)C8=O)=C9C=C5CS(=O)(C)=O)=O)=CC(O)=C4)=O)C(C)(C)C)=O

• Molecular Weight:

  1150.27

• References & Citations:

  [1]Dragovich PS, et, al. Antibody-Mediated Delivery of Chimeric BRD4 Degraders. Part 2: Improvement of In Vitro Antiproliferation Activity and In Vivo Antitumor Efficacy. J Med Chem. 2021 Mar 11;64(5):2576-2607.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported