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PROTAC BRD4 Degrader-14

CAT: 0804-HY-138637Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-138637Size:1 Each
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Description
PROTAC BRD4 Degrader-14 is a PROTAC connected by ligands for von Hippel-Lindau and BRD4, with IC50s of 1.8 nM and 1.7 nM for BRD4 BD1 and BD2, respectively. PROTAC BRD4 Degrader-14 is capable of potently degrading the BRD4 protein in PC3 prostate cancer cells[1].
CAS Number
3026420-43-6
UNSPSC
12352005
Target
Epigenetic Reader Domain; PROTACs
Type
Reference compound
Related Pathways
Epigenetics; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-brd4-degrader-14.html
Solubility
10 mM in DMSO
Smiles
O[C@H](C[C@H]1C(NCC2=CC=C(C=C2)C3=C(N=CS3)C)=O)CN1C([C@@H](NC(COCCC4=CC(OCCNC(C5=CC(N(C6=NC=C(F)C=C6F)CC7=CNC8=C7C9=CN(C)C8=O)=C9C=C5CS(=O)(C)=O)=O)=CC(O)=C4)=O)C(C)(C)C)=O
Molecular Formula
C57H61F2N9O11S2
Molecular Weight
1150.27
References & Citations
[1]Dragovich PS, et, al. Antibody-Mediated Delivery of Chimeric BRD4 Degraders. Part 2: Improvement of In Vitro Antiproliferation Activity and In Vivo Antitumor Efficacy. J Med Chem. 2021 Mar 11;64 (5) :2576-2607.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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