Seco-DUBA

• Target:

  DNA Alkylation|||ADC Cytotoxin

• Related Pathways:

  DNA Damage/DNA Repair|||Antibody-drug Conjugate/ADC Related

• Purity:

  0.9981

• Bioactivity:

  Seco-DUBA is an anticancer DNA alkylating agent and prodrug of DUBA, which can be used as a cytotoxic antibody-drug conjugate (ADC) . It has an IC50 of 18 nM against KB and 430 pM against SK-OV-3, and can be converted into DUBA with higher stability and activity in vivo.

• Smiles:

  C(Cl)[C@H]1C2=C(N(C(=O)C=3N=C4N(C3)C=C(NC(=O)C5=CC=C(O)C=C5)C=C4)C1)C=C(O)C=6C2=C(C)C=CC6

• Molecular Formula:

  C29H23ClN4O4

• Molecular Weight:

  526.97

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1227961-59-2