Seco-DUBA

CAT: 0931-T38611-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0931-T38611-01Size:1 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1227961-59-2
Target
DNA Alkylation|||ADC Cytotoxin
Related Pathways
DNA Damage/DNA Repair|||Antibody-drug Conjugate/ADC Related
Purity
0.9981
Bioactivity
Seco-DUBA is an anticancer DNA alkylating agent and prodrug of DUBA, which can be used as a cytotoxic antibody-drug conjugate (ADC) . It has an IC50 of 18 nM against KB and 430 pM against SK-OV-3, and can be converted into DUBA with higher stability and activity in vivo.
Smiles
C(Cl)[C@H]1C2=C(N(C(=O)C=3N=C4N(C3)C=C(NC(=O)C5=CC=C(O)C=C5)C=C4)C1)C=C(O)C=6C2=C(C)C=CC6
Molecular Formula
C29H23ClN4O4
Molecular Weight
526.97
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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