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Antitrypanosomal agent 1

CAT: 0804-HY-W052512-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-W052512-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Antitrypanosomal agent 1 is a potent and selective trypanothione reductase (TR) inhibitor with an IC50 of 3.3 μM. Antitrypanosomal agent 1 inhibits glutathione reductase (GR) (IC50=64.8 μM) and T. brucei (EC50=1 μM) . Antitrypanosomal agent 1 has anti-trypanosomal activity[1].
CAS Number
75144-12-6
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Parasite
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/antitrypanosomal-agent-1.html
Purity
99.50
Solubility
DMSO : 14.58 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 10 mg/mL (ultrasonic)
Smiles
O=C(C1=CC=C(Cl)C(Cl)=C1)CCN(C)C.[H]Cl
Molecular Formula
C11H14Cl3NO
Molecular Weight
282.60
Precautions
H302, H315, H319, H335
References & Citations
[1]Martyn DC, et al. High-throughput screening affords novel and selective trypanothione reductase inhibitors with anti-trypanosomal activity. Bioorg Med Chem Lett. 2007 Mar 1;17 (5) :1280-3.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Trypanosoma

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