Antitrypanosomal agent 8

• Description:

  Antitrypanosomal agent 8 (compound 3b) has potent antitrypanosomal activity against Trypanosoma brucei with an IC50 value of 0.79 μM and exhibits certain cytotoxicity in L6 cells (IC50=80.95 μM) [1].

• UNSPSC:

  12352005

• Target:

  Parasite

• Type:

  Reference compound

• Related Pathways:

  Anti-infection

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/antitrypanosomal-agent-8.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(NC1=CC=C(C(C)=O)C=C1)CSC2=NN=C(C3=CC=NC=C3)N2C4=CC=CC=C4

• Molecular Formula:

  C23H19N5O2S

• Molecular Weight:

  429.49

• References & Citations:

  [1]Shaykoon MS, et al. Design, synthesis and antitrypanosomal activity of heteroaryl-based 1,2,4-triazole and 1,3,4-oxadiazole derivatives. Bioorg Chem. 2020 Jul;100:103933.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  Trypanosoma

• CAS Number:

  [332376-42-8]