Antitrypanosomal agent 24

• Description:

  Antitrypanosomal agent 24 is a benzothiazole amidoxime with strong and selective antitrypanosomal activity (IC50 = 0.92 μM) . Antitrypanosomal agent 24 is a substrate of the P-glycoprotein efflux pump. Antitrypanosomal agent 24 has high membrane permeability and good metabolic stability. Antitrypanosomal agent 24 binds to DNA/RNA by intercalation[1].

• UNSPSC:

  12352005

• Target:

  P-glycoprotein

• Related Pathways:

  Membrane Transporter/Ion Channel

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection

• Smiles:

  N/C(C1=CC=C2C(SC(C3=CC=C(OCCN(CC)CC)C(F)=C3)=N2)=C1)=N\O

• Molecular Formula:

  C20H23FN4O2S

• Molecular Weight:

  402.49

• References & Citations:

  [1]Kaulić, V. R., et al., (2025) . Syntheses of benzothiazole amidoximes and arylimidamides and evaluation of their ADME and DNA binding properties and activity against Trypanosoma brucei. European journal of medicinal chemistry, 296, 117854. Advance online publication.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported