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Antitrypanosomal agent 6

CAT: 0804-HY-147549Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-147549Size:1 Each
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Description
Antitrypanosomal agent 6 (compound 18a) is a potent and antitrypanosomal agent with favorable ADME properties. Antitrypanosomal agent 6 is > 2-fold more potent against Trypanosoma brucei (T. brucei) than Nifurtimox, with an IC50 value of 0.47 μM. Antitrypanosomal agent 6 has strong interaction to DNA and can bind with high selectivity to AT-rich DNA[1].
CAS Number
2492436-35-6
UNSPSC
12352005
Target
Parasite
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/antitrypanosomal-agent-6.html
Solubility
10 mM in DMSO
Smiles
CCN(CCOC1=CC=C(C2=NC3=CC(C4=NCCN4)=CC=C3N2)C=C1)CC.[H]Cl.[H]Cl
Molecular Formula
C22H29Cl2N5O
Molecular Weight
450.40
References & Citations
[1]Popov AB, et al. Design, synthesis, antitrypanosomal activity, DNA/RNA binding and in vitro ADME profiling of novel imidazoline-substituted 2-arylbenzimidazoles. Eur J Med Chem. 2020;207:112802.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Trypanosoma

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