Antitrypanosomal agent 13

• Description :

  Antitrypanosomal agent 13 (compound 4b) is a potent antitrypanosomal agent. Antitrypanosomal agent 13 has trypanocidal and cytotoxic activity with GI50 values of 0.18 and 8.4 μM for T. brucei and HL-60, respectively[1].

• UNSPSC :

  12352005

• Target :

  Parasite

• Type :

  Reference compound

• Related Pathways :

  Anti-infection

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Infection

• Assay Protocol :

  https://www.medchemexpress.com/antitrypanosomal-agent-13.html

• Solubility :

  10 mM in DMSO

• Smiles :

  CC[C@H]([C@@H]1[C@@H](C)C[C@@H](C)[C@@]2(CC[C@H](NC(NCCCC)=S)[C@@]3(O[C@@]([C@@H]4O[C@@H](C)[C@@](O)(CC)CC4)(C)CC3)O2)O1)C([C@H]([C@@H](O)[C@H](C)[C@]5([H])O[C@@H]([C@H](C(O[Na])=O)CC)CC[C@@H]5C)C)=O

• Molecular Formula :

  C47H81N2NaO10S

• Molecular Weight :

  889.21

• References & Citations :

  [1]Antoszczak M, et, al. Synthesis of urea and thiourea derivatives of C20-epi-aminosalinomycin and their activity against Trypanosoma brucei. Eur J Med Chem. 2023 Mar 15;250:115241.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [9007-83-4]