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Antitrypanosomal agent 15

CAT: 0804-HY-155103Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-155103Size:1 Each
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Description
Antitrypanosomal agent 15 (compound 26) is an orally active, brain-penetrant, selective inhibitor against Trypanosoma cruzi proteasome, with an pIC50 of 7.4 and cruzi and human proteasome, respectively. Antitrypanosomal agent 15 has favorable ADME properties and can be used for Chagas disease study[1].
CAS Number
2961381-94-0
UNSPSC
12352005
Target
Parasite; Proteasome
Type
Reference compound
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/antitrypanosomal-agent-15.html
Solubility
10 mM in DMSO
Smiles
CNC(C1=C(F)C=CC(NC(C2=NN(C(C=C2)=O)CC3=CC=C(OC)C=C3)=O)=C1)=O
Molecular Formula
C21H19FN4O4
Molecular Weight
410.40
References & Citations
[1]Thomas MG, et al. Structure-Guided Design and Synthesis of a Pyridazinone Series of Trypanosoma cruzi Proteasome Inhibitors. J Med Chem. 2023;66 (15) :10413-10431.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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