Antitrypanosomal agent 15

Antitrypanosomal agent 15

• CAS Number: 9007-83-4
• UNSPSC Description: Antitrypanosomal agent 15 (compound 26) is an orally active, brain-penetrant, selective inhibitor against Trypanosoma cruzi proteasome, with an pIC50 of 7.4 and cruzi and human proteasome, respectively. Antitrypanosomal agent 15 has favorable ADME properties and can be used for Chagas disease study[1].
• Target Antigen: Parasite; Proteasome
• Type: Reference compound
• Related Pathways: Anti-infection;Metabolic Enzyme/Protease
• Applications: COVID-19-immunoregulation
• Field of Research: Infection
• Assay Protocol: https://www.medchemexpress.com/antitrypanosomal-agent-15.html
• Solubility: 10 mM in DMSO
• Smiles: CNC(C1=C(F)C=CC(NC(C2=NN(C(C=C2)=O)CC3=CC=C(OC)C=C3)=O)=C1)=O
• Molecular Weight: 410.40
• References & Citations: [1]Thomas MG, et al. Structure-Guided Design and Synthesis of a Pyridazinone Series of Trypanosoma cruzi Proteasome Inhibitors. J Med Chem. 2023;66(15):10413-10431.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported