Antitrypanosomal agent 7
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804-HY-147550
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Antitrypanosomal agent 7
- CAS Number: 9007-83-4
- UNSPSC Description: Antitrypanosomal agent 7 (compound 18c) is a potent and antitrypanosomal agent with favorable ADME properties. Antitrypanosomal agent 7 is > 2-fold more potent against Trypanosoma brucei (T. brucei) than Nifurtimox, with an IC50 value of 0.71 μM. Antitrypanosomal agent 7 has strong interaction to DNA and can bind with high selectivity to AT-rich DNA[1].
- Target Antigen: Parasite
- Type: Reference compound
- Related Pathways: Anti-infection
- Applications: COVID-19-immunoregulation
- Field of Research: Infection
- Assay Protocol: https://www.medchemexpress.com/antitrypanosomal-agent-7.html
- Solubility: 10 mM in DMSO
- Smiles: COC1=CC(C2=NC3=CC(C4=NCCN4)=CC=C3N2)=CC=C1OCCN(CC)CC.[H]Cl.[H]Cl
- Molecular Weight: 480.43
- References & Citations: [1]Popov AB,et al. DNA/RNA binding and in vitro ADME profiling of novel imidazoline-substituted 2-arylbenzimidazoles. Eur J Med Chem. 2020 Dec 1;207:112802.
- Shipping Conditions: Room temperature
- Clinical Information: No Development Reported