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BMS-599626

CAT: 0804-HY-10251-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-10251-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BMS-599626 (AC480) is a selective and orally bioavailable HER1 and HER2 inhibitor, with IC50s of 20 and 30 nM, respectively. BMS-599626 displays ~8-fold less potent to HER4 (IC50=190 nM), >100-fold to VEGFR2, c-Kit, Lck, MEK. BMS-599626 inhibits tumor cell proliferation, and has potential to increase tumor response to radiotherapy[1][2].
CAS Number
714971-09-2
Product Name Alternative
AC480
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
EGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bms-599626.html
Purity
98.56
Solubility
DMSO : 110 mg/mL (ultrasonic)
Smiles
O=C(NC1=CN2C(C(NC3=CC4=C(N(CC5=CC=CC(F)=C5)N=C4)C=C3)=NC=N2)=C1C)OC[C@H]6NCCOC6
Molecular Formula
C27H27FN8O3
Molecular Weight
530.55
Precautions
H302, H315, H319, H335
References & Citations
[1]Wong TW, et al. Preclinical antitumor activity of BMS-599626, a pan-HER kinase inhibitor that inhibits HER1/HER2 homodimer and heterodimer signaling. Clin Cancer Res. 2006 Oct 15;12 (20 Pt 1) :6186-93.|[2]Torres MA, et al. AC480, formerly BMS-599626, a pan Her inhibitor, enhances radiosensitivity and radioresponse of head and neck squamous cell carcinoma cells in vitro and in vivo. Invest New Drugs. 2011 Aug;29 (4) :554-61.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Citation 01
BMC Pulm Med. 2023 May 11;23 (1) :162.|Sci Transl Med. 2018 Jul 18;10 (450) :eaaq1093.|Life Sci. 2021 Dec 16;289:120231.

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A2822-5AC480 (BMS-599626)
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FDC17272BMS 599626-d4
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