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AF-45

CAT: 0804-HY-162641Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-162641Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AF-45 inhibits IRAK4 and IRAK1, with IC50s of 128 nM and 1765 nM. AF-45 inhibits the release of IL-6 and TNF-α in macrophages, with IC50s of 0.53-1.54 μM and 0.6-2.75 μM. AF-45 is also an inhibitor for NF-κB/MAPK signaling pathway. AF-45 exhibits anti-inflammatory activities against DSS-induced ulcerative colitis and Lipopolysaccharide -induced acute lung injury in mouse model. AF-45 exhibits good pharmacokinetic characteristics in rat models[1].
UNSPSC
12352005
Target
IRAK; NF-κB; p38 MAPK; TNF Receptor
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation; MAPK/ERK Pathway; NF-κB
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/af-45.html
Smiles
COC1=CC2=C(N=CN=C2O[C@H]3CC[C@@H](N)CC3)C=C1OCC4=CC=CC=C4
Molecular Formula
C22H25N3O3
Molecular Weight
379.45
References & Citations
[1]Zou Y, et al., Fragment-Based Anti-inflammatory Agent Design and Target Identification: Discovery of AF-45 as an IRAK4 Inhibitor to Treat Ulcerative Colitis and Acute Lung Injury. J Med Chem. 2024 Jun 24.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IRAK1; IRAK4

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