AF-2112

• UNSPSC Description:

  AF-2112 is a Flufenamic acid-derived TEAD inhibitor hat strongly reduce the expression of CTGF, Cyr61, Axl and NF2.

• Target Antigen:

  YAP

• Type:

  Reference compound

• Related Pathways:

  Stem Cell/Wnt

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/af-2112.html

• Solubility:

  10 mM in DMSO

• Smiles:

  OC(C1=CC=C(F)C=C1NC2=CC(OCCC3=CC=CC=C3)=CC=C2)=O

• Molecular Weight:

  351.37

• References & Citations:

  [1]Ahmed Fnaiche, et al. Development of LM-41 and AF-2112, two flufenamic acid-derived TEAD inhibitors obtained through the replacement of the trifluoromethyl group by aryl rings. Bioorg Med Chem Lett. 2023 Oct 15:95:129488.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2996821-62-4