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AF-2112

CAT: 0804-HY-155310-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-155310-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AF-2112 is a Flufenamic acid-derived TEAD inhibitor hat strongly reduce the expression of CTGF, Cyr61, Axl and NF2.
CAS Number
[2996821-62-4]
UNSPSC
12352005
Target
YAP
Type
Reference compound
Related Pathways
Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/af-2112.html
Purity
99.82
Solubility
DMSO : 200 mg/mL (ultrasonic)
Smiles
OC(C1=CC=C(F)C=C1NC2=CC(OCCC3=CC=CC=C3)=CC=C2)=O
Molecular Formula
C21H18FNO3
Molecular Weight
351.37
References & Citations
[1]Ahmed Fnaiche, et al. Development of LM-41 and AF-2112, two flufenamic acid-derived TEAD inhibitors obtained through the replacement of the trifluoromethyl group by aryl rings. Bioorg Med Chem Lett. 2023 Oct 15:95:129488.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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