AF-2785

CAT: 0804-HY-116806Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-116806Size:1 Each
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AF-2785 is a potent CFTR blocker. AF-2785 inhibits the cAMP-activated chloride current in rat epididymal cells with an IC50 of 170.6 μM. AF-2785 can be used in research related to contraceptives[1].
CAS Number
[252025-48-2]
UNSPSC
12352005
Target
CFTR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/af-2785.html
Smiles
O=C(O)/C=C\C1=NN(CC2=C(Cl)C=C(Cl)C=C2)C3=CC=CC=C31
Molecular Formula
C17H12Cl2N2O2
Molecular Weight
347.20
References & Citations
[1]Gong XD, et al. Lonidamine and analogue AF2785 block the cyclic adenosine 3', 5'-monophosphate-activated chloride current and chloride secretion in the rat epididymis. Biol Reprod. 2000 Sep;63 (3) :833-8.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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