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AF-353

CAT: 0804-HY-14483-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-14483-01Size:5 mg
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Description
AF-353 (Ro-4) is a potent, selective and orally bioavailable P2X3/P2X2/3 receptor antagonist, with a pIC50 of 8.0 for both human and rat P2X3, and with a pIC50 of 7.3 for human P2X2/3[1][2].
CAS Number
865305-30-2
Product Name Alternative
Ro-4
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
P2X Receptor
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/AF-353.html
Concentration
10mM
Purity
99.53
Solubility
DMSO : 83.33 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
CC(C)C1=C(OC2=CN=C(N)N=C2N)C=C(I)C(OC)=C1
Molecular Formula
C14H17IN4O2
Molecular Weight
400.21
Precautions
H302, H315, H319, H335
References & Citations
[1]Gever JR, et al. AF-353, a novel, potent and orally bioavailable P2X3/P2X2/3 receptor antagonist. Br J Pharmacol. 2010 Jul;160 (6) :1387-1398.|[2]Munoz A, et al. Modulation of bladder afferent signals in normal and spinal cord-injured rats by purinergic P2X3 and P2X2/3receptors. BJU Int. 2012 Oct;110 (8 Pt B) :E409-414.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
P2X3 Receptor

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BA165790-01AF 353

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