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AF-45

CAT: 0013-GTR19262831-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19262831-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AF-45 inhibits IRAK4 and IRAK1 with IC50 values of 128 nM and 1765 nM, respectively. It suppresses the release of IL-6 and TNF-α in macrophages, with IC50 ranges of 0.53-1.54 μM and 0.6-2.75 μM, respectively. Additionally, AF-45 acts as an inhibitor of the NF-κB/MAPK signaling pathway. In mouse models, AF-45 exhibits anti-inflammatory activity against DSS-induced ulcerative colitis and lipopolysaccharide-induced acute lung injury. In rat models, AF-45 demonstrates favorable pharmacokinetic properties.
Field of Research
Cell Biology, Immunology & Inflammation, Signal Transduction
Molecular Formula
C22H25N3O3
Storage Conditions
-20°C
Notes
For research use only.

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