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HDAC6-IN-45

CAT: 0804-HY-161783Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-161783Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HDAC6-IN-45 (Compound 15) is a selective inhibitor for HDAC6 with IC50 of 15.2 nM. HDAC6-IN-45 exhibits neurotrophic through the upregulation of GAP43 and Beta-3 tubulin markers. HDAC6-IN-45 activates the Nrf2 signaling pathway, reduces H2O2-induced ROS production, inhibits apoptosis in PC12, and exhibits neuroprotective efficacy in SCOP-induced zebrafish Alzheimer's Disease models. HDAC6-IN-45 exhibits antioxidant activity and good blood-brain barrier (BBB) permeability[1].
CAS Number
3048532-05-1
UNSPSC
12352005
Target
Apoptosis; HDAC; Keap1-Nrf2; Reactive Oxygen Species (ROS)
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/hdac6-in-45.html
Smiles
O=C(NO)C(C=C1)=CC=C1CN(CC2)CC3=C2C4=CC(F)=CC=C4N3CC5CC5
Molecular Formula
C23H24FN3O2
Molecular Weight
393.45
References & Citations
[1]Liang T, et al., Multimechanism biological profiling of tetrahydro--carboline analogues as selective HDAC6 inhibitors for the treatment of Alzheimer's disease. Eur J Med Chem. 2024 Jun 24;275:116624.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC1; HDAC2; HDAC3; HDAC6

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