SHP2-IN-45

• Description :

  SHP2-IN-45 is a potent, highly selective, and orally effective SHP2 allosteric inhibitor. SHP2-IN-45 significantly reduce the expression of IL-6, TNF-α, IL-1β, and iNOS mRNA. SHP2-IN-45 inhibits polarization of M1 macrophages. SHP2-IN-45 can inhibit the NF-κB pathway. SHP2-IN-45 can be used for research on sepsis and acute lung injury[1].

• UNSPSC :

  12352005

• Target :

  Interleukin Related; NF-κB; NO Synthase; SHP2; TNF Receptor

• Related Pathways :

  Apoptosis; Immunology/Inflammation; NF-κB; Protein Tyrosine Kinase/RTK

• Field of Research :

  Inflammation/Immunology

• Smiles :

  CC1=C2C([C@H](CCN(C3=NC=C(SC4=CC=NC(N)=C4Cl)N=C3)C2)N)=CC=C1

• Molecular Formula :

  C20H21ClN6S

• Molecular Weight :

  412.94

• References & Citations :

  [1]Jiang W, et al. Discovery of Potent and Orally bioavailable Benzoazepinamine-Based SHP2 Allosteric Inhibitors for the Treatment of Inflammatory Diseases. J Med Chem. 2025 Oct 20.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  IL-1; IL-6; iNOS; NF-κB

• CAS Number :

  [2949435-53-2]