PROTAC SMARCA2/4-degrader-19

• UNSPSC Description:

  PROTAC SMARCA2/4-degrader-19 (Compound I-412) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex SMARCA2 and SMARCA4. PROTAC SMARCA2/4-degrader-19 degrades SMARCA2 in MV411 and in A549 with DC50 SMARCA4 in MV411 with DC50 [1]

• Target Antigen:

  Epigenetic Reader Domain; PROTACs

• Type:

  Reference compound

• Related Pathways:

  Epigenetics;PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/protac-smarca2-4-degrader-19.html

• Smiles:

  CC1=NC(N2C3CN(C4=C(N)N=NC(C5=C(C=CC=C5)O)=C4)CC2CC3)=NC=C1[C@@H]6CC[C@H](CC6)C(N[C@@H](C(C)(C)C)C(N7[C@@H](C[C@H](C7)O)C(NCC8=CC=C(C9=C(N=CS9)C)C=C8)=O)=O)=O

• Molecular Weight:

  928.16

• References & Citations:

  [1]Ji N, et al., Smarca degraders and uses thereof. US20230072658A1.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2568277-57-4