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PROTAC SMARCA2 degrader-9

CAT: 0804-HY-162746Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-162746Size:1 Each
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Description
PROTAC SMARCA2 degrader-9 (compound I-285) is a PROTAC degrader targeting SMARCA2; it degrades SMARCA2 proteins in A549 cells with an DC50 90 after 24 h of treatment[1].
CAS Number
2568276-39-9
UNSPSC
12352005
Target
PROTACs
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-smarca2-degrader-9.html
Smiles
OC1=CC=CC=C1C2=CC(N3CC4CCC(N4C5=NC=C(N6CCN(CCCC7=CC(N(C)C(N8C9CCC(NC9=O)=O)=O)=C8C=C7)CC6)C=N5)C3)=C(N)N=N2
Molecular Formula
C40H46N12O4
Molecular Weight
758.87
References & Citations
[1]Preparation of heterocyclic compounds as SMARCA degraders and uses thereof. World Intellectual Property Organization, WO2020251971 A1 2020-12-17.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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