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MPO-IN-6

CAT: 0804-HY-163332Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-163332Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MPO-IN-6 (compound ADC) is an electrophile with good antioxidant and anti-inflammatory properties. MPO-IN-6 is a myeloperoxidase (MPO), dipeptidyl peptidase-4 (DPP-4), and α-glucosidase (α-GD) inhibitor with IC50s of 10 μM, 31.02 μM, and 46.05 μM, respectively. MPO-IN-6 is a potential cardiovascular preventive agent[1].
UNSPSC
12352005
Target
Dipeptidyl Peptidase; Glutathione Peroxidase; Glycosidase
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
Neuroscience-Neurodegeneration
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/mpo-in-6.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=C([N+]([O-])=O)C=C(OCO2)C2=C1)NC3=CC=CC(C(C)=O)=C3
Molecular Formula
C16H12N2O6
Molecular Weight
328.28
References & Citations
[1]Reshma Rajan, et al. Synthesis, Structural Elucidation, In Silico and In Vitro Studies of New Class of Methylenedioxyphenyl-Based Amide Derivatives as Potential Myeloperoxidase Inhibitors for Cardiovascular Protection. ACS Omega. 2024 Feb 7;9 (7) :7850-7868.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
DPP-4

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