MPO-IN-1

MPO-IN-1

• CAS Number: 2471981-21-0
• UNSPSC Description: MPO-IN-1 is a potent, orally active, and irreversible indole-containing inhibitor of myeloperoxidase (MPO). MPO-IN-1 has IC50s of 2.6 μM and 5.3 μM for MPO and thyroid peroxidase (TPO), respectively. MPO-IN-1 inhibits MPO activity in an acute mouse model of inflammation[1].
• Target Antigen: Glutathione Peroxidase
• Type: Reference compound
• Related Pathways: Apoptosis;Metabolic Enzyme/Protease
• Applications: COVID-19-immunoregulation
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/mpo-in-1.html
• Solubility: DMSO : 200 mg/mL (ultrasonic;warming;heat to 60°C)
• Smiles: ClC1=C(C(C2=CC3=C(C=CN3)C=C2)=CN4C5=CC=C(CN(C)C)C=C5)C4=NC=C1
• Molecular Weight: 400.90
• References & Citations: [1]Patnaik A, et al. Discovery of a novel indole pharmacophore for the irreversible inhibition of myeloperoxidase (MPO). Bioorg Med Chem. 2020;28(12):115548.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported