MPO-IN-9

• Description:

  MPO-IN-9 is a selective inhibitor of myeloperoxidase (MPO), with an IC50 value of 3.9 nM. MPO-IN-9 inhibits MPO-mediated ROS production and protects NO-dependent vascular function by blocking MPO's chlorination and peroxidation cycles. MPO-IN-9 can be used for the study of diseases such as chronic kidney disease (CKD), non-alcoholic steatohepatitis (NASH) [1].

• UNSPSC:

  12352005

• Target:

  Reactive Oxygen Species (ROS)

• Related Pathways:

  Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

• Field of Research:

  Inflammation/Immunology

• Smiles:

  O=C1C2=C(C=CN2)N(CC3=CC=CN=C3[C@H]4C[C@@H](C(F)(F)F)CCN4)C(N1)=S

• Molecular Formula:

  C18H18F3N5OS

• Molecular Weight:

  409.43

• References & Citations:

  [1]

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [3030264-54-8]