MPO-IN-5

MPO-IN-5

• CAS Number: 2476764-11-9
• UNSPSC Description: MPO-IN-5 (compound 1) is a potent, irreversible MPO (myeloperoxidase) inhibitor. MPO-IN-5 inhibits MPO peroxidation and hERG binding, with IC50 values of 0.22 and 2.8 μM, respectively. MPO-IN-5 shows rapid kinetics of inhibition, with enzyme inactivation rate (kinact/Ki) of 23000 M−1s−1[1].
• Target Antigen: Glutathione Peroxidase; Potassium Channel
• Type: Reference compound
• Related Pathways: Apoptosis;Membrane Transporter/Ion Channel;Metabolic Enzyme/Protease
• Applications: COVID-19-immunoregulation
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/mpo-in-5.html
• Solubility: 10 mM in DMSO
• Smiles: NC1=C2C(C3=CC4=C(C=C3)C=CN4)=CN(C2=NC=N1)C5=CC=C(C=C5)OCCNCCO
• Molecular Weight: 428.49
• References & Citations: [1]Patnaik A, et al. Discovery of a novel indole pharmacophore for the irreversible inhibition of myeloperoxidase (MPO). Bioorg Med Chem. 2020 Jun 15;28(12):115548.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported