MPO-IN-5

• Description:

  MPO-IN-5 (compound 1) is a potent, irreversible MPO (myeloperoxidase) inhibitor. MPO-IN-5 inhibits MPO peroxidation and hERG binding, with IC50 values of 0.22 and 2.8 μM, respectively. MPO-IN-5 shows rapid kinetics of inhibition, with enzyme inactivation rate (kinact/Ki) of 23000 M−1s−1[1].

• UNSPSC:

  12352005

• Target:

  Glutathione Peroxidase; Potassium Channel

• Type:

  Reference compound

• Related Pathways:

  Apoptosis; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/mpo-in-5.html

• Solubility:

  10 mM in DMSO

• Smiles:

  NC1=C2C(C3=CC4=C(C=C3)C=CN4)=CN(C2=NC=N1)C5=CC=C(C=C5)OCCNCCO

• Molecular Formula:

  C24H24N6O2

• Molecular Weight:

  428.49

• References & Citations:

  [1]Patnaik A, et al. Discovery of a novel indole pharmacophore for the irreversible inhibition of myeloperoxidase (MPO) . Bioorg Med Chem. 2020 Jun 15;28 (12) :115548.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [2476764-11-9]