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MPO-IN-4

CAT: 0804-HY-146651Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-146651Size:1 Each
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Description
MPO-IN-4 (compound 12) is a potent and selective myeloperoxidase (MPO) inhibitor with an IC500 of 25 nM. MPO-IN-4 has no effect on methyl guanine methyl transferase (MGMT) [1].
CAS Number
2088545-68-8
UNSPSC
12352005
Target
Glutathione Peroxidase
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/mpo-in-4.html
Solubility
10 mM in DMSO
Smiles
NC1=CC(CC2=CC=CC=C2)=C3N=NNC3=N1
Molecular Formula
C12H11N5
Molecular Weight
225.25
References & Citations
[1]Scott A Shaw, et al. Discovery and structure activity relationships of 7-benzyl triazolopyridines as stable, selective, and reversible inhibitors of myeloperoxidase. Bioorg Med Chem. 2020 Nov 15;28 (22) :115723.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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