MPO-IN-4
CAT:
804-HY-146651
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
MPO-IN-4
- CAS Number: 2088545-68-8
- UNSPSC Description: MPO-IN-4 (compound 12) is a potent and selective myeloperoxidase (MPO) inhibitor with an IC500 of 25 nM. MPO-IN-4 has no effect on methyl guanine methyl transferase (MGMT)[1].
- Target Antigen: Glutathione Peroxidase
- Type: Reference compound
- Related Pathways: Apoptosis;Metabolic Enzyme/Protease
- Applications: COVID-19-immunoregulation
- Field of Research: Inflammation/Immunology; Cardiovascular Disease
- Assay Protocol: https://www.medchemexpress.com/mpo-in-4.html
- Solubility: 10 mM in DMSO
- Smiles: NC1=CC(CC2=CC=CC=C2)=C3N=NNC3=N1
- Molecular Weight: 225.25
- References & Citations: [1]Scott A Shaw, et al. Discovery and structure activity relationships of 7-benzyl triazolopyridines as stable, selective, and reversible inhibitors of myeloperoxidase. Bioorg Med Chem. 2020 Nov 15;28(22):115723.
- Shipping Conditions: Room temperature
- Clinical Information: No Development Reported