MPO-IN-8

MPO-IN-8

• CAS Number: 62578-87-4
• UNSPSC Description: MPO-IN-8 is an orally active myeloperoxidase (MPO) inhibitor. MPO-IN-8 can inhibit the generation of hypochlorous acid in neutrophils and the release of extracellular traps (NETosis). In mice with gouty arthritis, MPO-IN-8 can reduce swelling, lower peroxidase activity, and decrease IL-1β levels[1].
• Target Antigen: Others
• Type: Reference compound
• Related Pathways: Others
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/mpo-in-8.html
• Smiles: O=C1C2=C3C(C(N1N)=O)=CC(N)=CC3=CC=C2
• Molecular Weight: 227.22
• References & Citations: [1]Matos IA, et al. Targeting Myeloperoxidase Ameliorates Gouty Arthritis: A Virtual Screening Success Story. J Med Chem. 2024 Jul 25;67(14):12012-12032.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported