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MPO-IN-8

CAT: 0804-HY-168002Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-168002Size:1 Each
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Description
MPO-IN-8 is an orally active myeloperoxidase (MPO) inhibitor. MPO-IN-8 can inhibit the generation of hypochlorous acid in neutrophils and the release of extracellular traps (NETosis) . In mice with gouty arthritis, MPO-IN-8 can reduce swelling, lower peroxidase activity, and decrease IL-1β levels[1].
CAS Number
62578-87-4
UNSPSC
12352005
Target
Others
Type
Reference compound
Related Pathways
Others
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/mpo-in-8.html
Smiles
O=C1C2=C3C(C(N1N)=O)=CC(N)=CC3=CC=C2
Molecular Formula
C12H9N3O2
Molecular Weight
227.22
References & Citations
[1]Matos IA, et al. Targeting Myeloperoxidase Ameliorates Gouty Arthritis: A Virtual Screening Success Story. J Med Chem. 2024 Jul 25;67 (14) :12012-12032.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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