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P-2281

CAT: 0804-HY-118704-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-118704-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
P-2281 is a mTOR inhibitor with anticancer and anti-inflammatory efficacies. P2281 inhibits mTOR activity in colon cancer cells. P-2281 suppresses Dextran sulfate sodium salt (DSS) -induced colitis by inhibiting T cell function and is efficacious in a murine model of human colitis[1].
CAS Number
1112994-35-0
Product Name Alternative
ACT-179811
UNSPSC
12352005
Hazard Statement
H301, H311, H331, H341
Target
MTOR
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/p-2281.html
Purity
99.81
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
CC(C(NC1=CC=C(N=C1)C#N)=O)Cl
Molecular Formula
C9H8ClN3O
Molecular Weight
209.63
Precautions
H301, H311, H331, H341
References & Citations
[1]Mandar R Bhonde, et al. A novel mTOR inhibitor is efficacious in a murine model of colitis. Am J Physiol Gastrointest Liver Physiol. 2008 Dec;295 (6) :G1237-45.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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