Products for Research Use Only
RegisterLogin

HCAIX-IN-23

CAT: 0804-HY-168030Size: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-168030Size:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
HCAIX-IN-23 (Compound 27) is a human carbonic anhydrase (hCA) inhibitor with Ki values of 10.4 and 8.5 nM for hCA IX and hCA XII, respectively. In addition to inhibiting hCA activity, hCAIX-IN-23 releases NO, exhibiting dual antitumor activity. hCAIX-IN-23 induces apoptosis by regulating mitochondrial caspase activity and the ferroptosis pathway (ferroptosis) through the downregulation of hCA IX and iron-regulatory protein expression. hCAIX-IN-23 is useful for renal cancer research[1].
UNSPSC
12352005
Target
Apoptosis; Carbonic Anhydrase; Caspase; Ferroptosis; Mitochondrial Metabolism; Reactive Oxygen Species (ROS)
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hcaix-in-23.html
Smiles
O=C(N(CCC1=CC=C(C=C1)S(=O)(N)=O)CC2=CC=CC=C2)C3=CC4=NO[N+]([O-])=C4C=C3
Molecular Formula
C22H20N4O5S
Molecular Weight
452.48
References & Citations
[1]Bua S, et al. Harnessing Nitric Oxide-Donating Benzofuroxans for Targeted Inhibition of Carbonic Anhydrase IX in Cancer. J Med Chem. 2024 Sep 12;67 (17) :15892-15907.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CA IX; CA XII

Related Products

CatalogName
HY-151406HCAIX-IN-13
HY-146007HCAIX-IN-17
HY-149301-01HCAIX-IN-18
HY-146983HCAIX-IN-3
HY-157135HCAIX-IN-19
HY-147662-01HCAIX-IN-5
HY-151633HCAIX-IN-14
HY-159128HCAIX-IN-21
HY-151632HCAIX-IN-15
HY-151630HCAIX-IN-16

Alternative Products

CatalogName
GTR19238796-01HCAIX-IN-23
T210086-01HCAIX-IN-20
T60745-01HCAIX-IN-5
T61237-01HCAIX-IN-6
T63158-01HCAIX-IN-10
T73030-01HCAIX-IN-14
MBS5823886hCAIX-IN-19
MBS5816444hCAIX-IN-17
MBS5804716hCAIX-IN-11
GTR19220775-01HCAIX-IN-13

Popular Products