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HCAIX-IN-3

CAT: 0804-HY-146983Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-146983Size:1 Each
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Description
HCAII-IN-3 (compound 7e) is a potent and selective inhibitor of carbonic anhydrase (CA II/IX) with Kis of 124.2 and 30.5 nM, respectively. hCAII-IN-3 has the potential for the research of cancer diseases[1].
CAS Number
2375461-31-5
UNSPSC
12352005
Target
Carbonic Anhydrase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hcaix-in-3.html
Solubility
10 mM in DMSO
Smiles
NS(=O)(OC1=CC=C(C=C1)NC(N2CCN(CC2)C3=NC(C4=CC=CC(Br)=C4)=CC=N3)=O)=O
Molecular Formula
C21H21BrN6O4S
Molecular Weight
533.40
References & Citations
[1]Nocentini A, et al. Sulfonamide/sulfamate switch with a series of piperazinylureido derivatives: Synthesis, kinetic and in silico evaluation as carbonic anhydrase isoforms I, II, IV, and IX inhibitors. Eur J Med Chem. 2020;186:111896.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CA II; CA IX

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