ACHN-975

• Description :

  ACHN-975 is a selective LpxC inhibitor and exhibits a subnanomolar LpxC inhibitory activity. ACHN-975 is against a wide range of gram-negative bacterias with low MIC values (≤1 μg/mL) [1].

• UNSPSC :

  12352005

• Hazard Statement :

  H302-H312-H332

• Target :

  Bacterial

• Type :

  Reference compound

• Related Pathways :

  Anti-infection

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Infection

• Assay Protocol :

  https://www.medchemexpress.com/achn-975.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(N[C@H](C(NO)=O)C(C)(N)C)C1=CC=C(C#CC#C[C@H]2[C@H](CO)C2)C=C1

• Molecular Formula :

  C20H23N3O4

• Molecular Weight :

  369.41

• Precautions :

  P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P363-P501

• References & Citations :

  [1]Kalinin DV, et al. Insights into the Zinc-Dependent Deacetylase LpxC: Biochemical Properties and Inhibitor Design. Curr Top Med Chem. 2016;16 (21) :2379-430.|[2]Krause KM, et al. Potent LpxC Inhibitors with In Vitro Activity against Multidrug-Resistant Pseudomonas aeruginosa.Antimicrob Agents Chemother. 2019 Oct 22;63 (11) . pii: e00977-19.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 1

• CAS Number :

  [1410809-36-7]