ACHN-975
CAT:
804-HY-19936
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
ACHN-975
- CAS Number: 1410809-36-7
- UNSPSC Description: ACHN-975 is a selective LpxC inhibitor and exhibits a subnanomolar LpxC inhibitory activity. ACHN-975 is against a wide range of gram-negative bacterias with low MIC values (≤1 μg/mL)[1].
- Target Antigen: Bacterial
- Type: Reference compound
- Related Pathways: Anti-infection
- Applications: COVID-19-immunoregulation
- Field of Research: Infection
- Assay Protocol: https://www.medchemexpress.com/achn-975.html
- Solubility: 10 mM in DMSO
- Smiles: O=C(N[C@H](C(NO)=O)C(C)(N)C)C1=CC=C(C#CC#C[C@H]2[C@H](CO)C2)C=C1
- Molecular Weight: 369.41
- References & Citations: [1]Kalinin DV, et al. Insights into the Zinc-Dependent Deacetylase LpxC: Biochemical Properties and Inhibitor Design. Curr Top Med Chem. 2016;16(21):2379-430.|[2]Krause KM,et al. Potent LpxC Inhibitors with In Vitro Activity against Multidrug-Resistant Pseudomonas aeruginosa.Antimicrob Agents Chemother. 2019 Oct 22;63(11). pii: e00977-19.
- Shipping Conditions: Room temperature
- Clinical Information: Phase 1