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AChE-IN-94

CAT: 0804-HY-175758Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-175758Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AChE-IN-94 is an orally active and blood-brain barrier penetrable AChE inhibitor with an IC50 of 0.40 μM and Ki of 0.28 μM. AChE-IN-94 prevents self-induced and AChE-mediated Aβ1-42 aggregation. AChE-IN-94 alleviates cognitive/memory deficits in Scopolamine -induced amnesic model. AChE-IN-94 can be used for the study of Alzheimer's disease (AD).
UNSPSC
12352005
Target
Amyloid-β; Cholinesterase (ChE)
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Smiles
O=C(NC1=NC2=CC=C(Cl)C=C2S1)CN3CCN(C(C4=CC=C(F)C=C4)=O)CC3
Molecular Formula
C20H18ClFN4O2S
Molecular Weight
432.90
References & Citations
[1]Bhardwaj B, et al. Novel benzothiazole-based cholinesterase inhibitors with amyloid beta disaggregation and antioxidant activity against Alzheimer's disease. Eur J Med Chem. 2025 Nov 15;298:118047.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AChE

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