AChE-IN-94

• Description:

  AChE-IN-94 is an orally active and blood-brain barrier penetrable AChE inhibitor with an IC50 of 0.40 μM and Ki of 0.28 μM. AChE-IN-94 prevents self-induced and AChE-mediated Aβ1-42 aggregation. AChE-IN-94 alleviates cognitive/memory deficits in Scopolamine (HY-N0296) -induced amnesic model. AChE-IN-94 can be used for the study of Alzheimer's disease (AD) [1].

• UNSPSC:

  12352005

• Target:

  Amyloid-β; Cholinesterase (ChE)

• Related Pathways:

  Neuronal Signaling

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Neurological Disease

• Smiles:

  O=C(NC1=NC2=CC=C(Cl)C=C2S1)CN3CCN(C(C4=CC=C(F)C=C4)=O)CC3

• Molecular Formula:

  C20H18ClFN4O2S

• Molecular Weight:

  432.90

• References & Citations:

  [1]Bhardwaj B, et al. Novel benzothiazole-based cholinesterase inhibitors with amyloid beta disaggregation and antioxidant activity against Alzheimer's disease. Eur J Med Chem. 2025 Nov 15;298:118047.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  AChE