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A-9758

CAT: 0804-HY-126252Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-126252Size:1 Each
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Description
A-9758 is a RORγ ligand and a potent, selective RORγt inverse agonist (IC50=5 nM), and exhibits robust potency against IL-17A release. A-9758 is effective in suppressing both Th17 differentiation and Th17 effector function. A-9758 significantly attenuates IL-23 driven psoriasiform dermatitis and is effective in blocking skin and joint inflammation[1].
CAS Number
[2055271-22-0]
UNSPSC
12352005
Target
Interleukin Related; ROR
Type
Reference compound
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/a-9758.html
Solubility
10 mM in DMSO
Smiles
O=C(C1CCN(C(C2=CC=C(Cl)C(CC(N3C)=CC4=C3C=C(C(F)(F)F)C=C4C)=C2Cl)=O)CC1)O
Molecular Formula
C25H23Cl2F3N2O3
Molecular Weight
527.36
References & Citations
[1]Gauld S, et al. Inhibition of IL-23 mediated inflammation with a novel small molecule inverse agonist of RORgt. J Pharmacol Exp Ther. 2019 Aug 2. pii: jpet.119.258046.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IL-17; IL-23; RORγ

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